BMJ Best Practice
最后审阅: 七月 2024
最后更新: 八月 2024

小结

定义

病史和体格检查

关键诊断因素

  • 腹泻
  • 腹胀
  • 腹痛/腹部不适
  • 贫血

其他诊断因素

  • 家族史
  • 骨质减少/骨质疏松症
  • 疲劳
  • 体重减轻

危险因素

  • 乳糜泻家族史
  • 免疫球蛋白 A 缺乏症
  • 1 型糖尿病
  • 自身免疫性甲状腺病

诊断性检查

首要检查

  • 抗组织转谷氨酰胺酶 IgA 抗体 (IgA-tTG)
  • IgA 定量检测
  • IgG DGP(脱酰胺醇溶蛋白肽)
  • 全血细胞计数 (FBC)
更多 首要检查

需考虑的检查

  • 人类白细胞抗原 (HLA) 分型
  • 麸质激发试验
  • 电视胶囊内镜检查
更多 需考虑的检查

治疗流程

撰稿人

Gastroenterologist, Celiac Center

Instructor in Medicine, Harvard Medical School

Beth Israel Deaconess Medical Center

Boston

MA

利益声明
AT is a site principal investigator for National Institute of Allergy and Infectious Diseases NIAID (IMX003 [latiglutenase]).

Associate Professor of Medicine and Epidemiology

Columbia University Irving Medical Center

New York

NY

利益声明
BL is an unpaid advisor for Nima Partners, Takeda, Teva, 9 Meters Biopharma, Bristol Myers Squibb, Mozart Therapeutics, and Alimentiv and a contractual researcher for Anokion. BL is an author of several references in this topic.

Dr Amelie Therrien and Dr Benjamin Lebwohl would like to gratefully acknowledge Professor Ciaran P. Kelly and Dr Daniel A. Leffler, previous contributors to this topic.

利益声明
DAL declares that he has no competing interests. CPK is a scientific advisor/consultant for Cour Pharma, Glutenostics, Immunogenx, Innovate, and Takeda Pharmaceuticals. He is an investigator for Aptalis and Takeda, and has stock options in Cour Pharma and Glutenostics. CPK is also a co-author of several references cited in this topic.

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Senior Clinical Lecturer and Honorary Consultant Gastroenterologist

Department of Infection, Immunity & Cardiovascular Disease

Sheffield Medical School

Sheffield

UK

利益声明
MK declares that he has no competing interests.

Professor of Medicine

Rosalind Franklin Medical School

Chicago

IL

利益声明
EDE declares that he has no competing interests.


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